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FACTOR XII
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DeCS
Descriptor
English
:
Factor XII
Descriptor
Spanish
:
Factor XII
Descriptor
Portuguese
:
Fator XII
Synonyms
English
:
Hageman Factor
Coagulation Factor XII
Tree Number:
D12.776.124.125.450
D23.119.450
Definition
English
:
Stable
blood coagulation
factor activated by contact with the subendothelial surface of an injured vessel. Along with
prekallikrein
, it serves as the contact factor that initiates the intrinsic pathway of
blood coagulation
. Kallikrein activates
factor XII
to XIIa. Deficiency of
factor XII
, also called the
Hageman trait
, leads to increased
incidence
of thromboembolic
disease
. Mutations in the gene for
factor XII
that appear to increase
factor XII
amidolytic activity are associated with
HEREDITARY ANGIOEDEMA TYPE III.
Entry Combination - descr/qualif
English
:
Factor XII
/
deficiency
use
Factor XII Deficiency
See Related
English
:
Coagulants
Hereditary Angioedema Type III
History Note
English
:
66(64)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DU
diagnostic use
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
22175
Unique Identifier:
D005174
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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